ea0011p627 | Neuroendocrinology and behaviour | ECE2006
Berg CA
, Pokrajac A
, Bidlingmaier M
, Strasburger CJ
, Mann K
, Shalet SM
, Trainer PJ
Approximately 50% of patients with severe AGHD (defined by the international consensus criteria, peak GH <3 ng/ml) have a normal age- and gender-related IGF-I. It remains unclear whether in these individuals IGF-I is GH-dependent. We performed a double-blind, randomised, placebo-controlled, cross-over study on the effect of pegvisomant (20 mg daily for 14 days) on the relationship between GH and IGF-I in 3 age-, gender- and BMI-matched cohorts (Norms: 5 GHD patients with n...